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Are you genuinely happy with your job?

I'm sure that many of us feel as is we're miserable at our jobs, but would we really be happier doing something else?  I've gone through the anguish and expense of changing careers in the past, and it turned out that it didn't really make a difference.  I think that the problem is me!  What is your experience with changing careers or even just changing jobs within the same career?  Did it make things better?